The Cathedral is located in the centre of the Muslim area and dates back to 1523. It has a nave and four aisles, a crossing and circular apse. Alonso Cano built the main façade with sculptures by Duque Cornejo, Risueño and Verdiguier while the only tower of the two planned ended up half finished. On the northern side, there is La Puerta del Perdón, a magnificent work of Diego de Siloé who also built La Puerta de San Jerónimo. The chancel is not only stunning, but includes skillful architectural solutions provided by Siloé. Its circular plan and great height contain semi-circular arches upon which a double series of balconies rest.

This cathedral with its five naves is considered to be the most important Renaissance building of Spain. Built in the transition period of Gothic to Renaissance, it shows as well elements of this earlier style. Especially remarkable are the main chapel, Capilla Mayor, the lateral chapels and of course the façade with its sculptures. Capilla Real The Royal Chapel was built between 1505 and 1521 under Spain's catholic kings. The northern front was later on integrated in the cathedral.